Emergent Communication in Interactive Sketch Question Answering

Vision-based emergent communication (EC) aims to learn to communicate through sketches and demystify the evolution of human communication. Ironically, previous works neglect multi-round interaction, which is indispensable in human communication. To fill this gap, we first introduce a novel Interactive Sketch Question Answering (ISQA) task, where two collaborative players are interacting through sketches to answer a question about an image in a multi-round manner. To accomplish this task, we design a new and efficient interactive EC system, which can achieve an effective balance among three evaluation factors, including the question answering accuracy, drawing complexity and human interpretability. Our experimental results including human evaluation demonstrate that multi-round interactive mechanism facilitates targeted and efficient communication between intelligent agents with decent human interpretability.Comment: Accepted by NeurIPS 202

Latency-Aware Collaborative Perception

Collaborative perception has recently shown great potential to improve perception capabilities over single-agent perception. Existing collaborative perception methods usually consider an ideal communication environment. However, in practice, the communication system inevitably suffers from latency issues, causing potential performance degradation and high risks in safety-critical applications, such as autonomous driving. To mitigate the effect caused by the inevitable latency, from a machine learning perspective, we present the first latency-aware collaborative perception system, which actively adapts asynchronous perceptual features from multiple agents to the same time stamp, promoting the robustness and effectiveness of collaboration. To achieve such a feature-level synchronization, we propose a novel latency compensation module, called SyncNet, which leverages feature-attention symbiotic estimation and time modulation techniques. Experiments results show that the proposed latency aware collaborative perception system with SyncNet can outperforms the state-of-the-art collaborative perception method by 15.6% in the communication latency scenario and keep collaborative perception being superior to single agent perception under severe latency.Comment: 14 pages, 11 figures, Accepted by European conference on computer vision, 202

Challenges and research opportunities for lung cancer screening in China

Abstract Following publication of the results of the National Lung Screening Trial in the United States, a randomized controlled trial in Italy (ITALUNG) and two simulation studies in China reported similar findings in 2017 favoring lung cancer screening with low-dose computed tomography among smokers. With such advances in lung cancer screening, worldwide interest has gradually shifted from evaluating whether refining lung cancer screening protocols is effective in preventing deaths. However, there are several practical problems to be resolved, including the balance of enrollment criteria and cost effectiveness, precise measurements to reduce false positive findings, risk-based optimization of screening frequency, challenges associated with cancer heterogeneity, strategies to combine image screening with novel biomarkers, dynamic monitoring of the natural history of cancer, accurate identification and diagnosis of cases among huge populations, and the impact of tobacco control policy and environment protection. As one in three individuals with lung cancer worldwide resides in China, these questions pose great challenges as well as research opportunities for population screening programs in China

Is exposure to tobacco associated with extrahepatic cholangiocarcinoma epidemics? A retrospective proportional mortality study in China

Abstract Background Extrahepatic cholangiocarcinoma (ECC) has become one of the most rapidly increasing malignancies in China during recent decades. The relationship between tobacco exposure and ECC epidemics is unclear; this study aimed to explore this relationship. Methods We included 55,806 participants aged 30 years or older from the National Mortality and Smoking Survey of China. Smoking in participants and spouses was defined as 1 cigarette or more per day for up to 1 year. Spouses’ smoking was taken as a measure of exposure to passive smoking. Smoking information in 1980 was ascertained and outcomes were defined as ECC mortality during 1986–1988. Results We found that either passive or active smoking increased the risk of death from ECC by 20% (risk ratio [RR], 1.20; 95% confidence interval [CI], 0.99–1.47), compared with no exposure to any tobacco. This risk was a notable 98% (RR, 1.98; 95% CI, 1.49–2.64) for individuals exposed to passive plus active smoking. These findings were highly consistent among men and women. Pathology-based analyses showed dose-response relationships of ECC with pack-years for all types of smoking exposure (Ps for trend < 0.05); the RR reached 2.75 (95% CI, 1.20–6.30) in individuals exposed to combined smoking with the highest exposure dose. The findings were similar for non-pathology-based analysis. Conclusions This study indicates that tobacco exposure increases ECC risk. Given the dramatic increase of exposure to secondhand smoke and patients with ECC, an inadequate provision of smoke-free environments could be contributing to ECC epidemics and could further challenge public health and medical services, based on the current disease spectrum

Mortality outcomes of low-dose computed tomography screening for lung cancer in urban China: a decision analysis and implications for practice

Abstract Background Mortality outcomes in trials of low-dose computed tomography (CT) screening for lung cancer are inconsistent. This study aimed to evaluate whether CT screening in urban areas of China could reduce lung cancer mortality and to investigate the factors that associate with the screening effect. Methods A decision tree model with three scenarios (low-dose CT screening, chest X-ray screening, and no screening) was developed to compare screening results in a simulated Chinese urban cohort (100,000 smokers aged 45–80 years). Data of participant characteristics were obtained from national registries and epidemiological surveys for estimating lung cancer prevalence. The selection of other tree variables such as sensitivities and specificities of low-dose CT and chest X-ray screening were based on literature research. Differences in lung cancer mortality (primary outcome), false diagnoses, and deaths due to false diagnosis were calculated. Sensitivity analyses were performed to identify the factors that associate with the screening results and to ascertain worst and optimal screening effects considering possible ranges of the variables. Results Among the 100,000 subjects, there were 448, 541, and 591 lung cancer deaths in the low-dose CT, chest X-ray, and no screening scenarios, respectively (17.2% reduction in low-dose CT screening over chest X-ray screening and 24.2% over no screening). The costs of the two screening scenarios were 9387 and 2497 false diagnoses and 7 and 2 deaths due to false diagnosis among the 100,000 persons, respectively. The factors that most influenced death reduction with low-dose CT screening over no screening were lung cancer prevalence in the screened cohort, low-dose CT sensitivity, and proportion of early-stage cancers among low-dose CT detected lung cancers. Considering all possibilities, reduction in deaths (relative numbers) with low-dose CT screening in the worst and optimal cases were 16 (5.4%) and 288 (40.2%) over no screening, respectively. Conclusions In terms of mortality outcomes, our findings favor conducting low-dose CT screening in urban China. However, approaches to reducing false diagnoses and optimizing important screening conditions such as enrollment criteria for screening are highly needed

Influence of Salt Intake on Association of Blood Uric Acid with Hypertension and Related Cardiovascular Risk.

A relationship of blood uric acid (UA) with hypertension and cardiovascular risk is under debate thus salt intake is hypothesized to contribute to such associations.In this cross-sectional study, stratified cluster random sampling elicited a sample of 1805 Kazakhs with 92.4% compliance. Hypertension and moderate-or-high total cardiovascular risk (mTCR) were defined according to guidelines. Sodium intake was assessed by urinary sodium excretion. Prevalence ratios (PRs) were used to express associations of UA with hypertension and mTCR.In the highest tertile of sodium intake in women, the adjusted PRs (95% confidence intervals) of low to high quartiles compared with the lowest quartile of UA, were 1.22(0.78-1.91), 1.18(0.75-1.85), and 1.65(1.09-2.51) for hypertension and 1.19(0.74-1.90), 1.39(0.91-2.11), and 1.65(1.10-2.47) for mTCR (P for trend <0.05). However, these findings were not shown for other sodium intake levels. There were similar results in men. PRs markedly increased with a concomitant increase in UA and sodium intake and there was a significant interaction (P = 0.010) for mTCR with PRs of 1.69(1.10-2.60) for men and 3.70(2.09-6.52) for women in those with the highest compared with the lowest quartile of UA and tertile of sodium intake. Similar findings were shown for hypertension.This study implied that a high salt intake may enhance the associations of UA with hypertension and cardiovascular risk

Can CT Screening Give Rise to a Beneficial Stage Shift in Lung Cancer Patients? Systematic Review and Meta-Analysis

<div><p>Objectives</p><p>To portray the stage characteristics of lung cancers detected in CT screenings, and explore whether there’s universal stage superiority over other methods for various pathological types using available data worldwide in a meta-analysis approach.</p><p>Materials and Methods</p><p>EMBASE and MEDLINE were searched for studies on lung cancer CT screening in natural populations through July 2015 without language or other filters. Twenty-four studies (8 trials and 16 cohorts) involving 1875 CT-detected lung cancer patients were enrolled and assessed by QUADAS-2. Pathology-confirmed stage information was carefully extracted by two reviewers. Stage I or limited stage proportions were pooled by random effect model with Freeman-Tukey double arcsine transformation.</p><p>Results</p><p>Pooled stage I cancer proportion in CT screenings was 73.2% (95% confidence interval: 68.6%, 77.5%), with a significant rising trend (<i>P</i>_trend<0.05) from baseline (64.7%) to ≥5 repeat rounds (87.1%). Relative to chest radiograph and usual care, the increased stage I proportions in CT were 12.2% (<i>P</i>>0.05), and 46.5% (<i>P</i><0.05), respectively. Pathology-specifically, adenocarcinomas (66%) and squamous cell lung cancers (17%) composed the majority of CT-detected lung cancers, and had significantly higher stage I proportions relative to chest radiograph (bronchioloalveolar adenocarcinomas, 80.9% vs 51.4%; other adenocarcinomas, 58.8% vs 38.3%; squamous cell lung cancers, 52.3% vs 38.3%; all <i>P</i><0.05). However, the percentage of small cell lung cancer was lower using CT than other detection routes, and no significant difference in limited stage proportion was observed (6.8% vs 10.8%, <i>P</i>>0.05).</p><p>Conclusion</p><p>CT screening can detect more early stage non-small cell lung cancers, but not all of them could be beneficial as there are a considerable number of indolent ones such as bronchioloalveolar adenocarcinomas. Still, current evidence is lacking regarding small cell lung cancers.</p></div

Basic characteristics of the included CT lung cancer screening studies.

<p>Basic characteristics of the included CT lung cancer screening studies.</p

Study selection flow chart.

<p>A list of the full-text excluded articles are available in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0164416#pone.0164416.s006" target="_blank">S2 Text</a>. ^a We excluded the two summary reports from the International Early Lung Cancer Action Program and another two reports of its individual sites because only clinical stage information could be obtained, which is heterogeneous to the pathological staging method and could overestimate the estimates in this study.</p

Individual patient data subgroup analysis of sources of heterogeneity regarding the proportion of stage I cancers in CT lung cancer screening studies.

<p>Individual patient data subgroup analysis of sources of heterogeneity regarding the proportion of stage I cancers in CT lung cancer screening studies.</p